Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

Endorphins are naturally occurring chemicals in the brain that help us manage pain and boost pleasure. Often called the body’s “natural opioids”, they are released during activities like exercise, laughing, eating, and social bonding. When endorphins flood the brain, we feel good — relaxed, happy, or even euphoric.

The landscape of alcohol recovery is undergoing a major transformation. For decades, abstinence was seen as the only viable path to recovery—often rigid, binary, and stigmatised. But science and innovation are rewriting that narrative. Today, we stand at the threshold of a new paradigm—one rooted in neuroscience, evidence, and personal empowerment.
